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pentobarbital will minimize the level or influence of abemaciclib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of abemaciclib with sturdy CYP3A4 inducers minimizes plasma focus of abemaciclib and its metabolites.pentobarbital will minimize the extent or impact of artemether/lumefantrine by